Abstract
It has been reported that malignancies of natural killer (NK) cell precursors, which are present in both myeloid and lymphoid antigens, are characterized by immature lymphoblastoid morphology with CD7+, CD33+ and CD56+ phenotype. Here, we report a 18-year-old man who was diagnosed with CD33- and CD13- NK cell precursor acute leukemia at first diagnosis. Following a 3-year remission state, he had a relapse as a testicular tumor and CD33+ myeloid/NK cell precursor acute leukemia after allogenic BMT. This case suggests that myeloid antigens are not necessary for diagnosis of myeloid/NK cell precursor acute leukemia.
MeSH terms
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Adolescent
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Antigens, CD / blood*
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Antigens, CD7 / blood
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Antigens, Differentiation, Myelomonocytic / blood*
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Bone Marrow Transplantation
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CD13 Antigens / blood*
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CD56 Antigen / blood
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Humans
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Killer Cells, Natural* / pathology
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Leukemia, Myeloid, Acute / blood*
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Leukemia, Myeloid, Acute / diagnosis*
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Leukemia, Myeloid, Acute / pathology
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Leukemia, Myeloid, Acute / therapy
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Male
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Recurrence
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Sialic Acid Binding Ig-like Lectin 3
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Testicular Neoplasms / blood*
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Testicular Neoplasms / diagnosis*
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Testicular Neoplasms / pathology
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Transplantation, Homologous
Substances
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Antigens, CD
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Antigens, CD7
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Antigens, Differentiation, Myelomonocytic
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CD33 protein, human
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CD56 Antigen
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Sialic Acid Binding Ig-like Lectin 3
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CD13 Antigens