New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis

Chem Pharm Bull (Tokyo). 2005 Sep;53(9):1175-7. doi: 10.1248/cpb.53.1175.

Abstract

Two new bisabolane-type sesquiterpenes, lippidulcine A (3) and epilippidulcine A (4), have been isolated from the aerial parts of Lippia dulcis TREV. along with five known flavonoids, cirsimaritin (5), salvigenin (6), eupatorin (7), 5-hydroxy-6,7,3',4'-tetramethoxyflavone (8) and 5,3'-dihydroxy-6,7,4',5'-tetramethoxyflavone (9), three known phenylethanoid glycosides, decaffeoylverbascoside (10), acteoside (11) and isoacteoside (12), and two known iridoid glucosides, 8-epiloganin (13) and lamiide (14). Their chemical structures have been determined on the basis of spectroscopic data. Among them, 5, 7, and 9 exhibited almost the same activity as that of alpha-tocopherol, and 10-12 were identified as stronger antioxidants than alpha-tocopherol using the ferric thiocyanate method.

MeSH terms

  • Antioxidants / chemistry
  • Carbohydrate Conformation
  • Chromatography, High Pressure Liquid
  • Iron / chemistry
  • Lippia / chemistry*
  • Magnetic Resonance Spectroscopy
  • Plant Extracts / chemistry
  • Plant Leaves / chemistry
  • Sesquiterpenes / chemistry*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Thiocyanates / chemistry

Substances

  • Antioxidants
  • Plant Extracts
  • Sesquiterpenes
  • Thiocyanates
  • epilippidulcine A
  • lippidulcine A
  • ferric thiocyanate
  • Iron