Abstract
Human coronavirus NL63 (HCoV-NL63), a newly discovered coronavirus, has been associated with acute respiratory tract infections (ARI). Important questions pertaining to the contribution of HCoV-NL63 to ARI and its impact on public health remain. We reviewed HCoV-NL63 in specimens collected from 13 November 2002 to 31 December 2003 from the Stollery Children's Hospital on patients of <17 years of age to assess the role of this virus in ARI in children. Twenty-six of 1,240 specimens (2.1%) from seven outpatients and 19 inpatients aged 7 days to 9.5 years tested positive for HCoV-NL63 by reverse transcription-PCR. The majority of outpatients (86%) had upper respiratory tract infections, while the majority of inpatients (58%) had bronchiolitis. Peak HCoV-NL63 activity occurred in March. These results provide further evidence of the importance of HCoV-NL63 in ARI in children.
MeSH terms
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Alberta / epidemiology
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Base Sequence
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Bronchiolitis / epidemiology*
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Bronchiolitis / virology
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Child
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Child, Preschool
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Coronavirus / classification
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Coronavirus / genetics
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Coronavirus / isolation & purification*
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Coronavirus Infections / epidemiology*
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Coronavirus Infections / virology
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Female
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Humans
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Infant
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Infant, Newborn
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Male
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Molecular Sequence Data
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Phylogeny
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Prevalence
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Respiratory Tract Infections / epidemiology*
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Respiratory Tract Infections / virology
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Sequence Analysis, DNA
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Viral Proteins / chemistry
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Viral Proteins / genetics
Substances
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Viral Proteins
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gene 1 protein, Coronavirus
Associated data
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GENBANK/AY567487
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GENBANK/AY567488
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GENBANK/AY567489
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GENBANK/AY567490
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GENBANK/AY567491
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GENBANK/AY567492
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GENBANK/AY567493
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GENBANK/AY567494
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GENBANK/AY675541
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GENBANK/AY675542
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GENBANK/AY675543
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GENBANK/AY675544
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GENBANK/AY675545
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GENBANK/AY675546
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GENBANK/AY675547
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GENBANK/AY675548
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GENBANK/AY675549
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GENBANK/AY675550
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GENBANK/AY675551
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GENBANK/AY675552
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GENBANK/AY675553
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GENBANK/AY746451
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GENBANK/AY746452
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GENBANK/AY746453
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GENBANK/AY746454
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GENBANK/AY746455
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GENBANK/AY746456
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GENBANK/AY746457
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GENBANK/AY746458
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GENBANK/AY758283
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GENBANK/AY758284
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GENBANK/AY758285
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GENBANK/AY758286
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GENBANK/AY758287
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GENBANK/AY758288
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GENBANK/AY758289