Impediment in upper airway stabilizing forces assessed by phrenic nerve stimulation in sleep apnea patients

Respir Res. 2005 Sep 7;6(1):99. doi: 10.1186/1465-9921-6-99.

Abstract

Background: The forces developed during inspiration play a key role in determining upper airway stability and the occurrence of nocturnal breathing disorders. Phrenic nerve stimulation applied during wakefulness is a unique tool to assess Upper airway dynamic properties and to measure the overall mechanical effects of the inspiratory process on UA stability.

Objectives: To compare the flow/pressure responses to inspiratory and expiratory twitches between sleep apnea subjects and normal subjects.

Methods: Inspiratory and expiratory twitches using magnetic nerve stimulation completed in eleven untreated sleep apnea subjects and ten normal subjects.

Results: In both groups, higher flow and pressure were reached during inspiratory twitches. The two groups showed no differences in expiratory twitch parameters. During inspiration, the pressure at which flow-limitation occurred was more negative in normals than in apneic subjects, but not reaching significance (p = 0.07). The relationship between pharyngeal pressure and flow adequately fitted with a polynomial regression model providing a measurement of upper airway critical pressure during twitch. This pressure significantly decreased in normals from expiratory to inspiratory twitches (-11.1 +/- 1.6 and -15.7 +/- 1.0 cm H2O respectively, 95% CI 1.6-7.6, p < 0.01), with no significant difference between the two measurements in apneic subjects. The inspiratory/expiratory difference in critical pressure was significantly correlated with the frequency of nocturnal breathing disorders.

Conclusion: Inspiratory-related upper airway dilating forces are impeded in sleep apnea patients.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diaphragm / innervation
  • Diaphragm / physiopathology*
  • Electric Stimulation
  • Exhalation
  • Female
  • Humans
  • Inhalation
  • Lung / innervation
  • Lung / physiopathology*
  • Male
  • Middle Aged
  • Muscle Contraction
  • Phrenic Nerve / physiopathology*
  • Respiratory Mechanics*
  • Sleep Apnea Syndromes / physiopathology*
  • Stress, Mechanical