Abstract
DNA microarray in 22 patients with acute leukemia revealed genes which were differentially expressed. Ribosomal protein SA (RPSA), minichromosome maintenance deficient 2 (MCM2) and heterogeneous nuclear ribonucleoprotein A1 (HNRPA1) were significantly upregulated (p<0.05, t test) in refractory patients, suggesting that they may play a role in refractoriness in acute leukemia and could be biomarkers of prognosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Biomarkers
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Biomarkers, Tumor*
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Cell Cycle Proteins / biosynthesis
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Female
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Gene Expression Regulation
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Gene Expression Regulation, Neoplastic*
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Heterogeneous Nuclear Ribonucleoprotein A1
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Heterogeneous-Nuclear Ribonucleoprotein Group A-B / biosynthesis
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Humans
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Leukemia / genetics*
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Leukemia / pathology*
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Male
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Middle Aged
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Minichromosome Maintenance Complex Component 2
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Nuclear Proteins / biosynthesis
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Nucleic Acid Hybridization
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Oligonucleotide Array Sequence Analysis
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Prognosis
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Receptors, Laminin / biosynthesis
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Ribosomal Proteins / biosynthesis
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Up-Regulation
Substances
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Biomarkers
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Biomarkers, Tumor
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Cell Cycle Proteins
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Heterogeneous Nuclear Ribonucleoprotein A1
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Heterogeneous-Nuclear Ribonucleoprotein Group A-B
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Nuclear Proteins
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RPSA protein, human
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Receptors, Laminin
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Ribosomal Proteins
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hnRNPA1 protein, human
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MCM2 protein, human
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Minichromosome Maintenance Complex Component 2