Prenatal diagnosis of alpha-1-antitrypsin deficiency by PCR of linked polymorphisms: a study of 17 cases

C M Abbott; J U Lovegrove; D B Whitehouse; D A Hopkinson; S Povey

doi:10.1002/pd.1970120402

Prenatal diagnosis of alpha-1-antitrypsin deficiency by PCR of linked polymorphisms: a study of 17 cases

Prenat Diagn. 1992 Apr;12(4):235-40. doi: 10.1002/pd.1970120402.

Authors

C M Abbott¹, J U Lovegrove, D B Whitehouse, D A Hopkinson, S Povey

Affiliation

¹ Department of Genetics and Biometry, University College London, U.K.

PMID: 1614981
DOI: 10.1002/pd.1970120402

Abstract

We describe our experiences of prenatal diagnosis of alpha-1-antitrypsin deficiency using closely linked polymorphisms detected by Southern blotting and the polymerase chain reaction. Prenatal diagnosis was carried out for 17 pregnancies from 15 couples.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Blotting, Southern
Chorionic Villi Sampling
Exons
Female
Genetic Linkage
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic
Pregnancy
Prenatal Diagnosis
alpha 1-Antitrypsin Deficiency*