Abstract
Background:
Blockage of tumour necrosis factor alpha (TNFalpha) is highly effective in rheumatic diseases, especially in rheumatoid arthritis (RA), ankylosing spondylitis, and psoriatic arthritis. Furthermore, TNFalpha antagonists have also been shown to significantly reduce psoriatic skin lesions.
Case reports:
A series of nine patients with RA who were treated with different types of TNFalpha antagonists and who unexpectedly developed either a new onset or an exacerbation of psoriatic skin lesions are reported.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adalimumab
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Adult
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Aged
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Antibodies, Monoclonal / adverse effects
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Antibodies, Monoclonal, Humanized
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Antirheumatic Agents / adverse effects*
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Arthritis, Rheumatoid / drug therapy*
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Etanercept
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Female
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Humans
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Immunoglobulin G / adverse effects
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Infliximab
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Male
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Middle Aged
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Psoriasis / chemically induced*
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Psoriasis / pathology
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Receptors, Tumor Necrosis Factor
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Antirheumatic Agents
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Immunoglobulin G
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Receptors, Tumor Necrosis Factor
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Tumor Necrosis Factor-alpha
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Infliximab
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Adalimumab
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Etanercept