Abstract
There is growing evidence for the role of voltage-gated L-type Ca2+ channels in mediating aspects of the addictive properties of psychostimulants. L-type Ca2+ channels activate Ca2+ second-messenger pathways that regulate protein phosphorylation and thereby activation of target gene expression. Here the authors will review recent progress in our understanding of L-type Ca2+ channel-activated signal transduction pathways that contribute to molecular neuroadaptations evident following acute and chronic exposures to psychostimulants.
MeSH terms
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Animals
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Calcium Channels, L-Type / chemistry
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Calcium Channels, L-Type / physiology*
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Central Nervous System Stimulants / pharmacology*
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Humans
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Models, Molecular
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Models, Neurological
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / physiology
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Phosphoric Monoester Hydrolases / metabolism*
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Phosphotransferases / metabolism*
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Signal Transduction / drug effects*
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Substance-Related Disorders / metabolism
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Substance-Related Disorders / physiopathology
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Ventral Tegmental Area / drug effects
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Ventral Tegmental Area / physiology
Substances
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Calcium Channels, L-Type
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Central Nervous System Stimulants
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Phosphotransferases
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Phosphoric Monoester Hydrolases