Abstract
The synthesis of a series of C3'-cis-substituted carboxycyclopropyl glycines bearing a wide variety of functional groups is described, and the structure-activity relationship for this series as agonists of group II metabotropic glutamate receptors is reported.
MeSH terms
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Crystallography, X-Ray
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Cyclization
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Glycine / chemical synthesis
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Glycine / chemistry*
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Glycine / pharmacology*
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Humans
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Molecular Structure
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Receptors, Metabotropic Glutamate / agonists*
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Receptors, Metabotropic Glutamate / metabolism*
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Structure-Activity Relationship
Substances
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Receptors, Metabotropic Glutamate
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metabotropic glutamate receptor 2
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metabotropic glutamate receptor 3
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Glycine