Immune tolerance induction with highly purified plasma-derived factor VIII containing von Willebrand factor in hemophilia A patients with high-responding inhibitors

Haematologica. 2005 Sep;90(9):1288-90.

Abstract

We retrospectively evaluated the efficacy of immune tolerance induction (ITI) in a homogenous cohort of eight patients with constitutive severe hemophilia A with high-responding factor VIII (FVIII) inhibitors using Facteur VIII-LFB/Factane, a highly purified FVIII concentrate containing von Willebrand factor (VWF).

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Factor VIII / antagonists & inhibitors*
  • Factor VIII / immunology*
  • Factor VIII / metabolism
  • Hemophilia A / blood
  • Hemophilia A / immunology*
  • Humans
  • Immune Tolerance*
  • Infant
  • Retrospective Studies
  • von Willebrand Diseases / blood
  • von Willebrand Diseases / immunology
  • von Willebrand Factor / antagonists & inhibitors*
  • von Willebrand Factor / immunology*
  • von Willebrand Factor / metabolism

Substances

  • von Willebrand Factor
  • Factor VIII