Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry

Chem Commun (Camb). 2005 Sep 28:(36):4581-3. doi: 10.1039/b507975f. Epub 2005 Aug 19.

Abstract

Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in yields ranging from 46 to 96%.

MeSH terms

  • Azides / chemistry
  • Cyclization
  • Dendrimers / chemical synthesis*
  • Electrophoresis, Polyacrylamide Gel
  • Magnetic Resonance Spectroscopy
  • Microwaves
  • Peptides / chemical synthesis*
  • Solvents
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Azides
  • Dendrimers
  • Peptides
  • Solvents