Synthesis and antitubercular activity of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes

Bioorg Med Chem Lett. 2005 Dec 1;15(23):5222-5. doi: 10.1016/j.bmcl.2005.08.045. Epub 2005 Sep 19.

Abstract

A series of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes were synthesized from nucleophilic opening of oxirane with different amines. These compounds were evaluated for their antitubercular activity against Mycobacterium tuberculosis H(37)R(v) in vitro and showed MIC in the range of 3.12-25microg/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / chemical synthesis*
  • Antitubercular Agents / chemistry
  • Antitubercular Agents / pharmacology*
  • Methane / chemistry
  • Mycobacterium tuberculosis / drug effects*
  • Phenanthrenes / chemical synthesis*
  • Phenanthrenes / chemistry
  • Phenanthrenes / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antitubercular Agents
  • Phenanthrenes
  • Methane