Abstract
Memory CD8+ T cells can be divided into two subsets, central memory (T(CM)) and effector memory (T(EM)) CD8+ T cells. We found that CD30, a member of the TNFR-associated factor (TRAF)-linked TNFR superfamily, signaling is involved in differentiation of long-lived CD8+ T(CM) cells following Listeria monocytogenes infection. Although CD8+ T(EM) cells transiently accumulated in the nonlymphoid tissues of CD30 ligand (CD153-/-) mice after infection, long-lived memory CD8+ T(CM) cells were poorly generated in these mice. CCR7 mRNA expression was down-regulated in CD8+ T cells of the spleen of CD153-/- mice in vivo and the expression was up-regulated in CD8+ T(EM) cells by anti-CD30 mAb cross-linking in vitro. These results suggest that CD30/CD30 ligand signaling plays an important role in the generation of long-lived memory CD8+ T cells at least partly by triggering homing receptors for T(CM) cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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CD30 Ligand
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CD8-Positive T-Lymphocytes / cytology
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CD8-Positive T-Lymphocytes / immunology*
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Cell Differentiation / genetics
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Cell Differentiation / immunology*
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Cell Survival / genetics
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Cell Survival / immunology
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Cells, Cultured
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Immunologic Memory* / genetics
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Ki-1 Antigen / physiology*
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Listeriosis / genetics
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Listeriosis / immunology
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Membrane Glycoproteins / deficiency
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / physiology*
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Mice
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Mice, Inbred BALB C
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Mice, Knockout
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Receptors, CCR7
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Receptors, Chemokine / biosynthesis
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Receptors, Chemokine / genetics
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Signal Transduction / genetics
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Signal Transduction / immunology*
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T-Lymphocyte Subsets / cytology
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T-Lymphocyte Subsets / immunology*
Substances
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CD30 Ligand
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Ccr7 protein, mouse
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Ki-1 Antigen
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Membrane Glycoproteins
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Receptors, CCR7
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Receptors, Chemokine
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Tnfsf8 protein, mouse