Abstract
In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4(+) T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Bacterial / blood*
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Antibodies, Bacterial / immunology
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Antigens, Bacterial / immunology*
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CD4-Positive T-Lymphocytes / immunology*
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Mice
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Mice, Inbred C57BL
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Nose / microbiology
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Pneumococcal Infections / immunology
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Pneumococcal Infections / prevention & control*
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Streptococcus pneumoniae / growth & development
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Streptococcus pneumoniae / immunology*
Substances
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Antibodies, Bacterial
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Antigens, Bacterial