Contrast-enhanced dark lumen PET/CT and MR colonography in a rodent polyp model: initial results with histopathologic correlation

Christiane A Kuehle; Patrick Veit; Gerald Antoch; Florian Grabellus; Philippe Robert; Thomas Beyer; Christoph U Herborn

doi:10.2214/AJR.04.1337

Contrast-enhanced dark lumen PET/CT and MR colonography in a rodent polyp model: initial results with histopathologic correlation

AJR Am J Roentgenol. 2005 Oct;185(4):1045-7. doi: 10.2214/AJR.04.1337.

Authors

Christiane A Kuehle¹, Patrick Veit, Gerald Antoch, Florian Grabellus, Philippe Robert, Thomas Beyer, Christoph U Herborn

Affiliation

¹ Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany.

PMID: 16177430
DOI: 10.2214/AJR.04.1337

Abstract

Objective: The objective of this study was to assess the feasibility of PET/CT for the detection of colorectal masses in a rodent polyp model in an intraindividual comparison with dark-lumen MR colonography.

Conclusion: Detection of small tumors with PET/CT and MR colonography is possible in a rodent model. The technique thus warrants further evaluation in animal studies as well as in patients with suspected colorectal disease.

MeSH terms

Animals
Colonic Polyps / diagnosis*
Colonic Polyps / pathology
Colonography, Computed Tomographic
Contrast Media
Disease Models, Animal
Feasibility Studies
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Rats
Rats, Wistar
Tomography, Emission-Computed

Substances

Contrast Media