Abstract
An oriental herbal combination (BDX-1) was isolated from Achyranthes bidentata and Atractylodes japonica. We previously tested the clinical effectiveness of BDX-1 in rheumatoid arthritis (RA) patients and found that it has a beneficial therapeutic effect. Here, we provide experimental evidence for the effectiveness of BDX-1 on RA in murine models. The oral administration of BDX-1 was found to markedly inhibit collagen-induced arthritis, adjuvant-induced arthritis, and zymosan-induced inflammation. It also inhibited carrageenan-induced acute edema and acetic acid-induced writhing response. In addition, the biological activity of BDX-1 was found to be strongly increased by fermentation. Our results suggest that BDX-1 could be useful for the treatment of rheumatoid arthritis.
MeSH terms
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Acetic Acid
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Achyranthes* / chemistry
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Arthritis, Experimental / chemically induced
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Arthritis, Experimental / pathology
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Arthritis, Experimental / prevention & control*
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Carrageenan
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Collagen
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Dose-Response Relationship, Drug
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Drugs, Chinese Herbal / administration & dosage
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Drugs, Chinese Herbal / pharmacology*
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Edema / chemically induced
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Edema / prevention & control
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Female
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Inflammation / chemically induced
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Inflammation / prevention & control
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Inbred DBA
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Pain / chemically induced
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Pain / prevention & control
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Rats
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Rats, Sprague-Dawley
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Zymosan
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Drugs, Chinese Herbal
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Carrageenan
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Collagen
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Zymosan
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Acetic Acid