Positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (mGluR2)

Curr Top Med Chem. 2005;5(9):869-84. doi: 10.2174/1568026054750281.

Abstract

This article describes recent medicinal chemistry progress toward selective potentiators of the metabotropic glutamate receptor 2 (mGluR2). Groups at Lilly and Merck have identified new classes of potentiators that exhibit selectivity for mGluR2 over the seven other subtypes of mGluRs. Structure-activity relationships as well as pharmacokinetic properties and in vivo activity are reviewed.

Publication types

  • Review

MeSH terms

  • Allosteric Regulation
  • Animals
  • Drug Design
  • Excitatory Amino Acid Agonists / pharmacokinetics*
  • Excitatory Amino Acid Agonists / pharmacology*
  • Humans
  • Receptors, Metabotropic Glutamate / agonists*
  • Receptors, Metabotropic Glutamate / metabolism
  • Structure-Activity Relationship

Substances

  • Excitatory Amino Acid Agonists
  • Receptors, Metabotropic Glutamate
  • metabotropic glutamate receptor 2