Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia

Caroline Holm; Ingrid Ora; Cecilia Brunhoff; Lola Anagnostaki; Göran Landberg; Jenny Liao Persson

doi:10.1016/j.leukres.2005.07.010

Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia

Leuk Res. 2006 Mar;30(3):254-61. doi: 10.1016/j.leukres.2005.07.010. Epub 2005 Sep 22.

Authors

Caroline Holm¹, Ingrid Ora, Cecilia Brunhoff, Lola Anagnostaki, Göran Landberg, Jenny Liao Persson

Affiliation

¹ Division of Pathology, Department of Laboratory Medicine, Lund University, University Hospital, 205 02 Malmö, Sweden.

PMID: 16182364
DOI: 10.1016/j.leukres.2005.07.010

Abstract

A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Age Factors
Biomarkers, Tumor / biosynthesis*
Child
Child, Preschool
Chromosome Aberrations
Cyclin A / biosynthesis*
Cyclin A1
Disease-Free Survival
Female
Gene Expression Regulation, Leukemic*
Humans
Infant
Male
Neoplasm Proteins / biosynthesis*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
Predictive Value of Tests

Substances

Biomarkers, Tumor
CCNA1 protein, human
Cyclin A
Cyclin A1
Neoplasm Proteins