A new antitumor compound from the plant Oryctanthus sp. as a VEGF receptor binding inhibitor

Vinod R Hegde; Haiyan Pu; Mahesh Patel; Adrian Jachens; Vincent P Gullo; Tze-Ming Chan

doi:10.1016/j.bmcl.2005.08.022

A new antitumor compound from the plant Oryctanthus sp. as a VEGF receptor binding inhibitor

Bioorg Med Chem Lett. 2005 Nov 15;15(22):4907-9. doi: 10.1016/j.bmcl.2005.08.022. Epub 2005 Sep 23.

Authors

Vinod R Hegde¹, Haiyan Pu, Mahesh Patel, Adrian Jachens, Vincent P Gullo, Tze-Ming Chan

Affiliation

¹ Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. [email protected]

PMID: 16183284
DOI: 10.1016/j.bmcl.2005.08.022

Abstract

The 70% aqueous methanolic extract of the Peruvian plant Oryctanthus sp. was found to contain a novel saccharide of a diene alpha,omega-diacid. Compound 1 was identified as an inhibitor of the VEGF receptor. The structure of this compound was established based on NMR studies. Compound 1 inhibited ligand binding to the VEGF receptor with an IC50 of 5.0 microM.

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology*
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Magnolia / chemistry*
Molecular Structure
Receptors, Vascular Endothelial Growth Factor / antagonists & inhibitors*
Receptors, Vascular Endothelial Growth Factor / metabolism

Substances

Antineoplastic Agents
Receptors, Vascular Endothelial Growth Factor