Abstract
The synthesis and biological activities of rapamycin (I) analogs modified at the C-40 position are reported. Emphasis placed on compounds that potentially have an improved safety profile on account of their shorter in vivo half-life when compared with rapamycin.
MeSH terms
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Animals
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Antirheumatic Agents / chemistry*
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Antirheumatic Agents / pharmacokinetics*
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Antirheumatic Agents / toxicity
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Arthritis, Rheumatoid / diagnostic imaging
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Arthritis, Rheumatoid / drug therapy
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Arthritis, Rheumatoid / metabolism*
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Male
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Radiography
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Rats
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Rats, Inbred Lew
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Rats, Sprague-Dawley
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Sirolimus / analogs & derivatives*
Substances
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Antirheumatic Agents
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Sirolimus