Abstract
Two alternative approaches to the synthesis of novel 6-(fluoromethyl)purine bases and nucleosides are described either by direct deoxyfluorination or by multistep functional group transformations starting from 6-(hydroxymethyl)purines. 6-(fluoromethyl)purine ribonucleoside displayed significant cytostatic effects.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Deaminase Inhibitors
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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HL-60 Cells
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Humans
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Purine Nucleosides / chemical synthesis*
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Purine Nucleosides / pharmacology
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Purines / chemical synthesis*
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Purines / pharmacology
Substances
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Adenosine Deaminase Inhibitors
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Antineoplastic Agents
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Purine Nucleosides
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Purines