Synthesis of highly functionalised spiro-indoles by a halogen atom transfer radical cyclization

Chem Commun (Camb). 2005 Oct 14:(38):4827-9. doi: 10.1039/b508424e. Epub 2005 Sep 2.

Abstract

The halogen atom transfer radical cyclization (HATRC) has been evaluated on N-(indolylmethyl)trichloroacetamides under Cu(I)Cl catalysis using nitrogen containing ligands. The ring closure leads to the formation of 3,3-spiro-3H-indoles in moderate to good yields by a 5-exo-mechanism. Derivatives with an N-electron withdrawing substituent also lead to a 5-exo-trig and not to a 6-endo-trig cyclization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Copper / chemistry*
  • Cyclization
  • Free Radicals / chemistry
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Ligands
  • Molecular Structure
  • Spiro Compounds / chemical synthesis*
  • Spiro Compounds / chemistry
  • Stereoisomerism

Substances

  • Free Radicals
  • Indoles
  • Ligands
  • Spiro Compounds
  • Copper
  • cuprous chloride
  • cupric chloride