Loss of apoptosis-inducing factor leads to an increase in reactive oxygen species, and an impairment of respiration that can be reversed by antioxidants

Cell Death Differ. 2006 Feb;13(2):354-7. doi: 10.1038/sj.cdd.4401776.

Authors

N Apostolova, A M Cervera, V M Victor, S Cadenas, A Sanjuan-Pla, A Alvarez-Barrientos, J V Esplugues, K J McCreath

PMID: 16195738
DOI: 10.1038/sj.cdd.4401776

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / pharmacology*
Apoptosis Inducing Factor / genetics
Apoptosis Inducing Factor / physiology*
Base Sequence
Cell Line, Tumor
Cell Respiration / drug effects
Cell Respiration / physiology*
Gene Expression Regulation / drug effects
Gene Silencing
Genetic Vectors
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / genetics
Hypoxia-Inducible Factor 1, alpha Subunit / physiology
Mitochondria / metabolism
Oxygen Consumption / drug effects
RNA, Small Interfering / pharmacology
Reactive Oxygen Species / metabolism*
Superoxides / metabolism

Substances

Antioxidants
Apoptosis Inducing Factor
HIF1A protein, human
Hypoxia-Inducible Factor 1, alpha Subunit
RNA, Small Interfering
Reactive Oxygen Species
Superoxides