The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist

Med Res Rev. 1992 Mar;12(2):149-91. doi: 10.1002/med.2610120203.
No abstract available

Publication types

  • Review

MeSH terms

  • Angiotensin II / antagonists & inhibitors*
  • Animals
  • Antihypertensive Agents* / chemistry
  • Antihypertensive Agents* / pharmacology
  • Antihypertensive Agents* / therapeutic use
  • Binding, Competitive
  • Biphenyl Compounds* / chemistry
  • Biphenyl Compounds* / pharmacology
  • Biphenyl Compounds* / therapeutic use
  • Clinical Trials as Topic
  • Drug Evaluation, Preclinical / methods*
  • Drug Evaluation, Preclinical / trends
  • Humans
  • Imidazoles* / chemistry
  • Imidazoles* / pharmacology
  • Imidazoles* / therapeutic use
  • Kallikrein-Kinin System / drug effects
  • Losartan
  • Models, Chemical
  • Rabbits
  • Rats
  • Renin-Angiotensin System / drug effects
  • Tetrazoles* / chemistry
  • Tetrazoles* / pharmacology
  • Tetrazoles* / therapeutic use

Substances

  • Antihypertensive Agents
  • Biphenyl Compounds
  • Imidazoles
  • Tetrazoles
  • Angiotensin II
  • Losartan