Abstract
Daptomycin is a new lipopeptide antibiotic that is rapidly bactericidal against Staphylococcus aureus. We report daptomycin resistance and treatment failure in 2 patients with osteomyelitis due to methicillin-resistant S. aureus. Disk diffusion susceptibility testing failed to detect resistance. Daptomycin at high concentration retained bactericidal activity against resistant isolates.
MeSH terms
-
Aged
-
Aged, 80 and over
-
Anti-Bacterial Agents / pharmacology*
-
Anti-Bacterial Agents / therapeutic use
-
Bacteremia / microbiology
-
Daptomycin / pharmacology*
-
Drug Resistance, Bacterial*
-
Female
-
Humans
-
Lumbar Vertebrae / microbiology
-
Lumbosacral Region / microbiology
-
Methicillin Resistance*
-
Microbial Sensitivity Tests / methods
-
Middle Aged
-
Osteomyelitis / microbiology
-
Staphylococcal Infections / microbiology
-
Staphylococcus aureus / drug effects*
-
Treatment Failure
Substances
-
Anti-Bacterial Agents
-
Daptomycin