Abstract
[reaction: see text] Benzene-fused cyclic sulfamates are prepared from ortho-substituted phenolic starting materials through selective C-H amination or olefin aziridination. These unique heterocycles will engage in Ni-catalyzed cross-coupling reactions with aryl- and alkyl-Grignard reagents. Application of modern tools for C-N and C-C bond formation thus makes readily available functional amine derivatives and augments the possible uses for C-H amination in synthesis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amination
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Benzene Derivatives / chemical synthesis*
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Benzene Derivatives / chemistry
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Catalysis
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Cross-Linking Reagents / chemistry*
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / chemistry
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Hydrogen Bonding
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Nickel / chemistry*
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Sulfonic Acids / chemical synthesis*
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Sulfonic Acids / chemistry
Substances
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Benzene Derivatives
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Cross-Linking Reagents
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Heterocyclic Compounds
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Sulfonic Acids
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Nickel
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sulfamic acid