A novel route to fully substituted 1H-pyrazoles

Yat Fan Suen; Håkon Hope; Michael H Nantz; Makhluf J Haddadin; Mark J Kurth

doi:10.1021/jo051319a

A novel route to fully substituted 1H-pyrazoles

J Org Chem. 2005 Oct 14;70(21):8468-71. doi: 10.1021/jo051319a.

Authors

Yat Fan Suen¹, Håkon Hope, Michael H Nantz, Makhluf J Haddadin, Mark J Kurth

Affiliation

¹ Department of Chemistry, University of California, Davis, California 95616, USA.

PMID: 16209593
DOI: 10.1021/jo051319a

Abstract

A novel one-step synthesis route to fully substituted pyrazol-4-ols is reported. This simple yet nonobvious method for the construction of pyrazol-4-ols by the condensation-fragmentation-cyclization-extrusion reactions of thietanones with 1,2,4,5-tetrazines is reported. All of the elements of the thietanone except its sulfur are incorporated in these novel products.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry
Hydrogen / chemistry
Models, Molecular
Molecular Structure
Pyrazoles / chemical synthesis*
Pyrazoles / chemistry*

Substances

Enzyme Inhibitors
Pyrazoles
Hydrogen