Abstract
The adiponectin paralog CORS-26 (collagenous repeat-containing sequence of 26kDa protein) is a member of the C1q/TNF-alpha molecular superfamily. CORS-26 is a secreted protein and baculovirus-produced CORS-26 released in the supernatant of insect cells forms stable trimers. Adiponectin exerts anti-inflammatory effects in LPS-treated monocytic cells and CORS-26 also reduces IL-6 and TNF-alpha secretion but does not increase IL-10. Suppression of NFkappaB signalling may explain the anti-inflammatory actions of CORS-26. Furthermore CORS-26 protein was detected in human monocytic and dendritic cells. The present data demonstrate for the first time that CORS-26 forms trimers, exerts anti-inflammatory properties and that it is expressed in monocytic cells. Therefore CORS-26 may provide a new target for pharmacological drugs in inflammatory diseases like the metabolic syndrome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Active Transport, Cell Nucleus / drug effects
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Animals
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Anti-Inflammatory Agents / metabolism*
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Anti-Inflammatory Agents / pharmacology*
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Baculoviridae / genetics
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Cell Line
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Cell Nucleus / metabolism
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Humans
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Interleukin-10 / metabolism
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Interleukin-6 / metabolism
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Monocytes / chemistry
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Monocytes / drug effects*
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Monocytes / metabolism*
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Proteins / genetics
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Proteins / metabolism*
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Proteins / pharmacology*
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RNA, Messenger / analysis
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RNA, Messenger / metabolism
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Recombinant Proteins / biosynthesis
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Recombinant Proteins / genetics
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Recombinant Proteins / pharmacology
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Transcription Factor RelA / metabolism
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Tumor Necrosis Factor-alpha / metabolism
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Tumor Necrosis Factors
Substances
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Anti-Inflammatory Agents
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C1QTNF3 protein, human
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Interleukin-6
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Proteins
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RNA, Messenger
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Recombinant Proteins
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Transcription Factor RelA
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Tumor Necrosis Factor-alpha
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Tumor Necrosis Factors
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Interleukin-10