Abstract
N,N'-Disubstituted ketene aminals are good bioisosteres of thiourea functional groups. We report the design and synthesis of a novel class of ketene aminal-based lactam derivatives as potent and orally active FXa inhibitors.
MeSH terms
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Administration, Oral
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Ethylenes / administration & dosage
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Ethylenes / chemistry
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Ethylenes / pharmacology*
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Factor Xa Inhibitors*
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Humans
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Ketones / administration & dosage
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Ketones / chemistry
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Ketones / pharmacology*
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Lactams / administration & dosage
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Lactams / pharmacology*
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Models, Molecular
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Molecular Conformation
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Structure-Activity Relationship
Substances
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Ethylenes
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Factor Xa Inhibitors
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Ketones
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Lactams
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ketene