Abstract
We report the synthesis and study of a photoreactive nitrobenzamide containing acridine that specifically interacts at abasic site in DNA by threading intercalation and introduces under irradiation a lesion on the opposite strand at the unpaired pyrimidine.
MeSH terms
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Acridines / chemistry*
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Benzamides / chemistry*
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DNA / chemistry*
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DNA Repair
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Dimerization
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Electrophoresis, Polyacrylamide Gel
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Intercalating Agents / pharmacology*
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Light
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Magnetic Resonance Spectroscopy
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Models, Chemical
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Models, Molecular
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Molecular Conformation
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Nitrobenzenes / chemistry*
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Nucleic Acid Conformation
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Nucleic Acid Denaturation
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Oligonucleotides / chemistry
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Protons
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Pyrimidines / chemistry*
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Temperature
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Thermodynamics
Substances
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Acridines
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Benzamides
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Intercalating Agents
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Nitrobenzenes
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Oligonucleotides
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Protons
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Pyrimidines
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DNA
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nitrobenzene
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pyrimidine