Abstract
We examined 348 patients who underwent thrombolytic treatment for acute myocardial infarction. Nine patients (2.58%) developed neurological complications related directly or indirectly to this procedure. Cerebral hemorrhage occurred in 3 patients; 2 patients had transient ischemic attacks, 1 had syncope, another had psychomotor agitation and 2 patients presented seizures during the infusion of the thrombolytic agent, without hemodynamic abnormalities. This latter feature had never been described before.
MeSH terms
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Adult
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Brain Diseases / drug therapy
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Brain Diseases / etiology
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Brain Diseases / physiopathology
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Cerebrovascular Disorders / drug therapy
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Cerebrovascular Disorders / etiology
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Enzyme Activation
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Female
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Fibrinolytic Agents*
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Heparin* / administration & dosage
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Humans
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Male
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Middle Aged
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Myocardial Infarction / complications
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Myocardial Infarction / physiopathology
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Myocardial Infarction / therapy*
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Phenytoin / therapeutic use
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Seizures / drug therapy
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Seizures / etiology
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Seizures / physiopathology
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Thrombolytic Therapy*
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Tissue Plasminogen Activator* / administration & dosage
Substances
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Fibrinolytic Agents
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Phenytoin
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Heparin
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Tissue Plasminogen Activator