Abstract
The authors used surface-based anatomic mapping to detect features of hippocampal anatomy that correlated with surgical outcomes in patients undergoing surgery for mesial temporal lobe epilepsy with hippocampal sclerosis. Compared with a seizure-free group, hippocampal profiles for the non-seizure-free group had greater diffuse ipsilateral atrophy and more region-specific contralateral atrophy in the anterior, lateral hippocampus. These atrophic regions may indicate areas of increased epileptogenicity, contributing to poorer surgical outcomes.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Atrophy / diagnosis*
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Atrophy / physiopathology
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Brain Mapping / methods*
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Epilepsy, Temporal Lobe / diagnosis*
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Epilepsy, Temporal Lobe / physiopathology
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Epilepsy, Temporal Lobe / surgery
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Female
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Hippocampus / pathology*
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Hippocampus / physiopathology
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Hippocampus / surgery
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Humans
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Imaging, Three-Dimensional
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Interviews as Topic
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Magnetic Resonance Imaging / methods*
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Male
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Models, Neurological
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Neurosurgical Procedures
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Patient Selection
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Predictive Value of Tests
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Preoperative Care / methods*