CSF levels of angiogenesis-related proteins in patients with leptomeningeal metastases

Neurology. 2005 Oct 11;65(7):1120-2. doi: 10.1212/01.wnl.0000178981.39984.c2.

Abstract

The authors determined the levels of vascular endothelial growth factor (VEGF) and urokinase-type plasminogen activator (uPA) in the CSF of patients with leptomeningeal metastases (LM; n = 53), cancer patients without LM (n = 18), and subjects without malignancy (n = 25). Median levels of uPA and VEGF were significantly higher in patients with LM, supporting the hypothesis that angiogenesis contributes to LM. VEGF was negatively correlated with survival in patients with LM, suggesting its use as a prognostic factor.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Arachnoid / blood supply
  • Arachnoid / pathology
  • Arachnoid / physiopathology
  • Biomarkers, Tumor / cerebrospinal fluid*
  • Blood Vessels / metabolism
  • Blood Vessels / pathology
  • Blood Vessels / physiopathology
  • Carcinoma / secondary
  • Female
  • Humans
  • Lymphoma, Non-Hodgkin / pathology
  • Male
  • Meningeal Neoplasms / cerebrospinal fluid*
  • Meningeal Neoplasms / diagnosis
  • Meningeal Neoplasms / secondary*
  • Middle Aged
  • Multiple Myeloma / secondary
  • Neoplasm Metastasis
  • Neovascularization, Pathologic / cerebrospinal fluid
  • Neovascularization, Pathologic / diagnosis*
  • Neovascularization, Pathologic / physiopathology
  • Pia Mater / blood supply
  • Pia Mater / pathology
  • Pia Mater / physiopathology
  • Predictive Value of Tests
  • Prognosis
  • Survival Rate
  • Urokinase-Type Plasminogen Activator / cerebrospinal fluid*
  • Vascular Endothelial Growth Factor A / cerebrospinal fluid*

Substances

  • Biomarkers, Tumor
  • Vascular Endothelial Growth Factor A
  • Urokinase-Type Plasminogen Activator