Abstract
Objectives:
Amisulpride is a substituted benzamide derivative with atypical antipsychotic properties and low side effects.
Method:
We report four cases of patients with clinically and genetically established Huntington's disease and signs of psychosis who were treated with Amisulpride.
Results:
Two patients developed extrapyramidal side effects due to the treatment. The antipsychotic therapy of all patients was effective.
Discussion:
Due to degeneration of striatal neurons patients suffering from Huntington's disease react early with development of extrapyramidal side effects after therapy with amisulpride.
MeSH terms
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Aged
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Amisulpride
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Antipsychotic Agents / adverse effects
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Antipsychotic Agents / therapeutic use*
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Delusions / diagnosis
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Delusions / drug therapy
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Delusions / genetics
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Delusions / psychology
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Drug Therapy, Combination
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Female
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Follow-Up Studies
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Humans
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Huntington Disease / diagnosis
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Huntington Disease / drug therapy*
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Huntington Disease / genetics
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Huntington Disease / psychology
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Male
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Middle Aged
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Neurologic Examination / drug effects
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Neuropsychological Tests
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Parkinson Disease, Secondary / chemically induced
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Parkinson Disease, Secondary / diagnosis
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Psychotic Disorders / diagnosis
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Psychotic Disorders / drug therapy
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Psychotic Disorders / genetics
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Psychotic Disorders / psychology
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Sulpiride / adverse effects
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Sulpiride / analogs & derivatives*
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Sulpiride / therapeutic use
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Treatment Outcome
Substances
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Antipsychotic Agents
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Sulpiride
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Amisulpride