Abstract
The effect of sodium butyrate (NaB) on cell growth and expression of morphological and biochemical properties was examined in the human neuroblastoma cell lines AF8 and SJ-N-KP. The obtained data show that NaB induced a marked growth inhibition and morphological differentiation, while it was ineffective in inducing biochemical differentiation.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetylcholinesterase / metabolism
-
Antibodies, Monoclonal
-
Butyrates / pharmacology*
-
Butyric Acid
-
Cell Differentiation / drug effects*
-
Cell Division / drug effects*
-
Cell Line
-
Chromogranin A
-
Chromogranins / analysis
-
HLA Antigens / analysis
-
HLA-DR Antigens / analysis
-
Humans
-
Immunohistochemistry
-
Neuroblastoma
-
Neurofilament Proteins / analysis
-
Phosphopyruvate Hydratase / analysis
-
Synaptophysin / analysis
-
Tumor Cells, Cultured
Substances
-
Antibodies, Monoclonal
-
Butyrates
-
Chromogranin A
-
Chromogranins
-
HLA Antigens
-
HLA-DR Antigens
-
Neurofilament Proteins
-
Synaptophysin
-
Butyric Acid
-
Acetylcholinesterase
-
Phosphopyruvate Hydratase