Abstract
Neonatal injection of sodium glutamate before injection of diethylnitrosamine decreased the number of tumor nodes in the liver of male mice, decreased the weight of the testes and adrenals and blood level of testosterone (but increased blood level of corticosterone), impaired recovery of diethylnitrosamine-disturbed sexual motivation in half of males. Anticarcinogenic effect of sodium glutamate is explained by feminization of males under its effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenal Glands / drug effects*
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Alkylating Agents / toxicity
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Animals
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Animals, Newborn
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Diethylnitrosamine / toxicity
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Female
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Food Additives / administration & dosage
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Food Additives / adverse effects*
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Liver Neoplasms, Experimental / chemically induced
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Liver Neoplasms, Experimental / pathology
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Liver Neoplasms, Experimental / physiopathology*
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Male
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Mice
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Mice, Inbred CBA
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Organ Size / drug effects
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Pregnancy
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Sexual Behavior, Animal / drug effects*
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Sodium Glutamate / administration & dosage
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Sodium Glutamate / adverse effects*
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Testis / drug effects
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Testosterone / blood
Substances
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Alkylating Agents
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Food Additives
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Diethylnitrosamine
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Testosterone
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Sodium Glutamate