Abstract
The concentrations of keratan sulfates and unmodified keratan sulfates increased in the vertebral body growth plate in patients with idiopathic scoliosis. Sulfation and acetylation of total glycosaminoglycans decreased by 50 and 30%, respectively. These changes reflect the decrease in biological activity of molecules that modulate function of the growth plate.
MeSH terms
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Acetylation
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Adolescent
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Case-Control Studies
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Glycosaminoglycans / analysis*
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Glycosaminoglycans / chemistry
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Growth Plate / chemistry*
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Growth Plate / physiopathology
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Humans
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Keratan Sulfate / analysis
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Keratan Sulfate / chemistry
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Scoliosis / metabolism*
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Scoliosis / physiopathology*
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Spine / chemistry*
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Spine / physiopathology
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Thoracic Vertebrae / chemistry
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Thoracic Vertebrae / physiopathology
Substances
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Glycosaminoglycans
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Keratan Sulfate