Abstract
A 6-year-old boy with known peripheral T-cell lymphoma had progressive left periorbital swelling and CT findings consistent with abscess or necrosis. Biopsy revealed peripheral T-cell lymphoma and associated necrosis involving the lacrimal gland and surrounding orbital tissue. Immunohistochemical and T-cell receptor gene rearrangement studies confirmed the diagnosis. The patient responded to local radiation and systemic chemotherapy. This is the first pathologically confirmed case of orbital peripheral T-cell lymphoma with subpanniculitic features.
MeSH terms
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Antineoplastic Agents, Phytogenic / therapeutic use
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Biomarkers, Tumor / metabolism
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Biopsy
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Child
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Combined Modality Therapy
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Gene Rearrangement, T-Lymphocyte / genetics
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Humans
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Lymphoma, T-Cell, Peripheral / diagnostic imaging
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Lymphoma, T-Cell, Peripheral / drug therapy
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Lymphoma, T-Cell, Peripheral / pathology*
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Lymphoma, T-Cell, Peripheral / radiotherapy
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Male
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Orbital Neoplasms / diagnostic imaging
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Orbital Neoplasms / drug therapy
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Orbital Neoplasms / pathology*
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Orbital Neoplasms / radiotherapy
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Receptors, Antigen, T-Cell, gamma-delta / genetics
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Tomography, X-Ray Computed
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Vinblastine / therapeutic use
Substances
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Antineoplastic Agents, Phytogenic
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Biomarkers, Tumor
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Receptors, Antigen, T-Cell, gamma-delta
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Vinblastine