Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient

Exp Clin Endocrinol Diabetes. 2005 Oct;113(9):538-40. doi: 10.1055/s-2005-872886.

Abstract

We treated a patient with type 2 diabetes suffering from chronic venous and neuro-ischemic wounds not healing under standard care with local application of autologous bone marrow cells (mBMC) isolated from bone marrow aspirate. This procedure led to a reduction of wound size, a markedly increased vascularization and infiltration of mononuclear cells, 7 days after treatment, without any signs of a systemic reaction to treatment. Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Marrow Cells*
  • Bone Marrow Transplantation*
  • Diabetes Mellitus, Type 2* / complications
  • Diabetes Mellitus, Type 2* / pathology
  • Diabetic Foot / etiology
  • Diabetic Foot / pathology
  • Diabetic Foot / therapy*
  • Female
  • Humans
  • Male
  • Neovascularization, Physiologic*
  • Recovery of Function
  • Transplantation, Autologous
  • Wound Healing*