The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs

Bioorg Med Chem Lett. 2006 Jan 1;16(1):142-5. doi: 10.1016/j.bmcl.2005.09.024. Epub 2005 Oct 19.

Abstract

For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n-butylmansonone F showed fourfold higher antibacterial activities compared to that of vancomycin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology
  • Drug Resistance, Bacterial
  • Methicillin / pharmacology
  • Models, Chemical
  • Naphthoquinones / chemistry*
  • Naphthoquinones / metabolism
  • Quinones / chemistry*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / metabolism
  • Staphylococcal Infections / drug therapy
  • Staphylococcus aureus / metabolism
  • Structure-Activity Relationship
  • Vancomycin / chemistry

Substances

  • Anti-Infective Agents
  • Naphthoquinones
  • Quinones
  • Sesquiterpenes
  • mansonone F
  • Vancomycin
  • Methicillin