Follicular lymphoma with bilateral testicular and epididymal involvement: case report and review of the literature

Leuk Lymphoma. 2005 Nov;46(11):1663-6. doi: 10.1080/10428190500178548.

Abstract

Testicular involvement with indolent lymphoma is extremely rare, particularly in the absence of transformation to an aggressive histology. We report a case of a 64-year-old man who presented with cervical lymphadenopathy. Staging CT scans revealed extensive lymphadenopathy as well as bilateral testicular and epididymal masses. Histologic examination of lymph node, bone marrow, and testicular/epididymal biopsies revealed involvement with grade I follicular lymphoma. The patient was started on chemotherapy with cyclophosphamide, vincristine, prednisone, and rituximab in addition to intrathecal methotrexate and testicular radiation. He is now 6 months into therapy and responding well. A review of the literature demonstrated this to be the first confirmed case of testicular and epididymal involvement with grade I follicular lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Epididymis / pathology*
  • Humans
  • Lymph Nodes / pathology
  • Lymphatic Irradiation
  • Lymphoma, Follicular / pathology*
  • Lymphoma, Follicular / therapy
  • Male
  • Middle Aged
  • Testicular Neoplasms / pathology*
  • Testicular Neoplasms / therapy
  • Tomography, X-Ray Computed