Sustained, spontaneous disappearance of serum HCV-RNA under immunosuppression after liver transplantation for HCV cirrhosis

Dimitrios N Samonakis; Evangelos Cholongitas; Christos K Triantos; Paul Griffiths; Amar Paul Dhillon; Ulrich Thalheimer; David W Patch; Andrew K Burroughs

doi:10.1016/j.jhep.2005.08.005

Sustained, spontaneous disappearance of serum HCV-RNA under immunosuppression after liver transplantation for HCV cirrhosis

J Hepatol. 2005 Dec;43(6):1091-3. doi: 10.1016/j.jhep.2005.08.005. Epub 2005 Sep 15.

Authors

Dimitrios N Samonakis¹, Evangelos Cholongitas, Christos K Triantos, Paul Griffiths, Amar Paul Dhillon, Ulrich Thalheimer, David W Patch, Andrew K Burroughs

Affiliation

¹ Liver Transplantation Hepatobiliary Unit, Royal Free Hospital, Pond Street, Hampstead, NW3 2QG London, UK.

PMID: 16239045
DOI: 10.1016/j.jhep.2005.08.005

Abstract

Immunosuppression is a main determinant for the increased Hepatitis C Virus (HCV) replication after liver transplantation and the accelerated course of recurrent HCV liver disease. We present two patients both with diabetes, renal dysfunction with proteinuria converted to sirolimus therapy, who cleared serum HCV RNA without antiviral treatment. This is a potentially important observation that should stimulate study into factors that may help viral clearance from blood.

Publication types

Case Reports

MeSH terms

Diabetes Mellitus, Type 1 / complications
Hepacivirus / immunology
Hepacivirus / isolation & purification*
Hepatitis C / complications
Hepatitis C / virology*
Humans
Immunosuppressive Agents / immunology*
Immunosuppressive Agents / therapeutic use
Liver Cirrhosis / therapy*
Liver Cirrhosis / virology
Liver Transplantation*
Male
Middle Aged
Proteinuria / complications
RNA, Viral*
Recurrence
Remission, Spontaneous
Renal Insufficiency / complications
Viral Load

Substances

Immunosuppressive Agents
RNA, Viral