Scaffolds for microtubule inhibition through extensive modification of the epothilone template

Angew Chem Int Ed Engl. 2005 Dec 1;44(45):7469-73. doi: 10.1002/anie.200501760.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Drug Screening Assays, Antitumor
  • Epothilones / chemical synthesis
  • Epothilones / chemistry*
  • Epothilones / pharmacology*
  • Humans
  • Microtubules / chemistry
  • Microtubules / drug effects*
  • Microtubules / metabolism
  • Molecular Conformation
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tubulin / chemical synthesis
  • Tubulin / chemistry
  • Tubulin / pharmacology

Substances

  • Epothilones
  • Tubulin