[Methodological studies on selectively removing toxins in Aristolochiae manshuriensis by chinese processing techniques]

Zhongguo Zhong Yao Za Zhi. 2005 Aug;30(16):1243-6.
[Article in Chinese]

Abstract

Objective: To investigate the possibility of selectively detoxifying aristolochic acids in Aristolochiae manshuriensis (Guanmutong) by the chemical properties of aristolochic acids and traditional Chinese processing experience.

Method: The technical parameters in processing technique of A. manshuriensis were optimized by orthogonal designed methods with aristolochic acid A.

Result: The processing technique was soaked in 0.1 mol x L(-1) baking soda for several times and then processing with vinegar. Temperature was important factor to detoxify aristolochic acids. aristolochic acid A were removed over 90% from A. manshuriensis in laboratory and over 80% in medium-scale production by 10 batches from two origins of botanical drugs with different contents, and decreased to 0.35-0.60 mg x g(-1) in processed products. aristolochic acid A existed mostly salt-forms in the botanical drug.

Conclusion: Most toxic components in Guanmutong could be removed by the new processing method.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Acid
  • Aristolochia / chemistry*
  • Aristolochic Acids / analysis*
  • Hot Temperature
  • Pharmaceutical Solutions / chemistry
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Sodium Bicarbonate
  • Technology, Pharmaceutical / methods*
  • Temperature

Substances

  • Aristolochic Acids
  • Pharmaceutical Solutions
  • Sodium Bicarbonate
  • aristolochic acid I
  • Acetic Acid