Abstract
Several cyclic ADP-carbocyclic-ribose analogs 3-10 modified in the N-1-carbocyclic-ribose moiety were synthesized. Their Ca2+-releasing activity was estimated in sea urchin eggs to show that the 3"-deoxy analog 6 shows 5 times more potent activity than cADPcR, but the 2",3"-didieoxy-2",3"-unsunsaturated analog 3 has very weak activity. We also calculated their stable conformation and found that 3 and 6 were significantly different in their stable conformation.
MeSH terms
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Adenosine Diphosphate / chemistry
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Animals
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Calcium / metabolism
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Cyclic ADP-Ribose / analogs & derivatives*
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Cyclic ADP-Ribose / chemistry
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Cyclic ADP-Ribose / pharmacology
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Dose-Response Relationship, Drug
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Models, Chemical
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Models, Molecular
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Molecular Biology / methods
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Molecular Conformation
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Protein Conformation
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Ribose / chemistry*
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Sea Urchins
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Structure-Activity Relationship
Substances
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cyclic ADP-carbocyclic-ribose
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Cyclic ADP-Ribose
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Adenosine Diphosphate
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Ribose
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Calcium