Halogenated helianane derivatives from the sponge Spirastrella hartmani

María Jesús Martín; Fabrice Berrué; Philippe Amade; Rogelio Fernández; Andrés Francesch; Fernando Reyes; Carmen Cuevas

doi:10.1021/np050247f

Halogenated helianane derivatives from the sponge Spirastrella hartmani

J Nat Prod. 2005 Oct;68(10):1554-5. doi: 10.1021/np050247f.

Authors

María Jesús Martín¹, Fabrice Berrué, Philippe Amade, Rogelio Fernández, Andrés Francesch, Fernando Reyes, Carmen Cuevas

Affiliation

¹ Medicinal Chemistry Department, PharmaMar S.A., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770 Colmenar Viejo, Madrid, Spain.

PMID: 16252925
DOI: 10.1021/np050247f

Abstract

Two new halogenated derivatives (1 and 2) of helianane (3) were isolated from the 2-propanol extract of the sponge Spirastrella hartmani. The structures of the new derivatives were determined on the basis of detailed spectroscopic analysis, including (+)-HREIMS and 1D and 2D NMR. Compound 1 showed in vitro cytotoxicity against the human tumor cell lines A549, HT29, and MDA-MB-231.

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Porifera / chemistry*
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Sesquiterpenes
helianane