Measurement of neutrophil membrane CD64 and HLA-Dr in a patient with abdominal sepsis

Wim van der Meer; Colin Stephen Scott; Carin Verlaat; Jacqueline Klein Gunnewiek; Adilia Warris

doi:10.1016/j.jinf.2005.09.003

Measurement of neutrophil membrane CD64 and HLA-Dr in a patient with abdominal sepsis

J Infect. 2006 Jul;53(1):e43-6. doi: 10.1016/j.jinf.2005.09.003. Epub 2005 Oct 25.

Authors

Wim van der Meer¹, Colin Stephen Scott, Carin Verlaat, Jacqueline Klein Gunnewiek, Adilia Warris

Affiliation

¹ Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. [email protected]

PMID: 16253335
DOI: 10.1016/j.jinf.2005.09.003

Abstract

A patient with abdominal sepsis, had both intra and extracellular bacteria in a blood smear, and high levels of neutrophil membrane CD64 and HLA-Dr. Intracellular bacteria are only observed in the terminal phase of a sepsis. Our patient recovered, suggesting that a high expression of neutrophil CD64 is indicative for a good prognosis.

Publication types

Case Reports

MeSH terms

Abdomen
Bacteremia / microbiology
Child, Preschool
Enterobacter aerogenes / isolation & purification
Enterobacteriaceae Infections / microbiology
Enterococcus faecalis / isolation & purification
Gram-Positive Bacterial Infections / microbiology
HLA-DR Antigens / metabolism*
Humans
Male
Neutrophils / immunology*
Neutrophils / microbiology
Receptors, IgG / metabolism*
Sepsis / etiology*
Sepsis / immunology*

Substances

HLA-DR Antigens
Receptors, IgG