The patella as the largest sesamoid bone of the human body forms the patellofemoral joint with the patellar groove of the femur. The patellofemoral joint is a complex articulation with high functional and biomechanical requirements. Several anatomical variants of both patella and the trochlea exist. Multiple clinical problems of the knee may be caused by anatomical and physiological abnormalities of this joint. Exact knowledge about the anatomy, the biomechanics and the function of the patellofemoral joint is therefore required to understand its wide range of pathology.