HIV infection and protease genetic diversity in a rural area of the Southern Central African Republic

J Med Virol. 2005 Dec;77(4):457-9. doi: 10.1002/jmv.20476.

Abstract

Thirty-eight of 175 (21.7%) consecutive women of childbearing age from a rural area near Bangassou were tested HIV-positive. Ten protease and two protease/reverse transcriptase sequences (31.5% samples) were obtained. Eight sequences clustered into subtype J, A, G; two sequences were 13_cpx recombinant forms and two were indeterminate. The high proportion of HIV found suggests a recent outbreak of diversified HIV strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Central African Republic / epidemiology
  • Female
  • Genetic Variation*
  • HIV Infections / epidemiology*
  • HIV Infections / virology
  • HIV Protease / genetics*
  • HIV Reverse Transcriptase / genetics*
  • HIV-1 / classification
  • HIV-1 / drug effects
  • HIV-1 / enzymology*
  • HIV-1 / genetics
  • Humans
  • Middle Aged
  • Phylogeny
  • Pregnancy

Substances

  • HIV Reverse Transcriptase
  • HIV Protease