Abstract
[structures: see text] Three novel C19 homolignans, designated taiwankadsurins A (1), B (2), and C (3), were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of 1-3, which have a 3,4-{1'-[(Z)-2''-methoxy-2''-oxo-ethylidene]}-pentano(2,3-dihydro-benzo[b]furano)-3-(2'''-methoxycarbonyl-2'''-hydroxy-2''',3'-epoxide) skeleton, were determined by spectroscopic analyses, especially 2D NMR techniques (HMBC and NOESY). Compound 2 exhibited mild cytotoxicity against human KB and Hela tumor cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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KB Cells
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Kadsura / chemistry*
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology
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Molecular Structure
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
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Taiwan
Substances
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Antineoplastic Agents, Phytogenic
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Lignans
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taiwankadsurin A
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taiwankadsurin B
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taiwankadsurin C